This a weird, off topic question, but I've got a
Focusrite 2i4 audio interface that I initially connected to my
M-Audio CX8 powered monitors with 1/4" TRS balanced cables using
the balanced connections on the Focusrite and the speakers. The
sound was disappointing, lacking both top end and bottom end.
It didn't occur to me to try the the unbalanced connections
on the Focusrite and the speakers until just the other day,
and the difference is startling. Much punchier and deep bass,
crisper highs. There is a little bit of digital hash from
computer interference, but I'll live with it for now because
the sound is so much better.