Micah, No, not really running into any issues at all with the Boomerang not being in an effects loop, though I do recommend not feeding a line level device into the 'rang without the 'rang being in an effects loop. Though I do have to agree that when the 'rang is run in front of my Carvin amp, vs. the Mesa Boogie it is a little bit less clean. Now that I've been rearranging everything at home, I've been using the Boomerang more and more with my GR-30 and running it through the effects loop on the GR-30 with much better and cleaner results. Another issue I'm finding is that you want to make absolutely sure that when you set your levels on the back of the 'rang that it isn't all that hot a signal hitting the 'rang otherwise mine tends to cut out on me in the middle of a loop. Though I have to admit, I'm having a majour blast with the Boomerang vs. my Tchus, Lee-ohki.